Government study comparing finasteride, dutasteride and placebo

https://clinicaltrials.gov/ct2/show/results/NCT01231607?show_locs=Y&sect=X430125&view=results#othr

ClinicalTrials.gov Identifier: NCT01231607

Recruitment Status: Completed

First Posted: November 1, 2010

Results First Posted: October 4, 2012

Last Update Posted: August 10, 2018

Sponsor: GlaxoSmithKline

Dutasteride 0.02 mg	Dutasteride 0.1 mg	Dutasteride 0.5 mg	Finasteride 1 mg	Placebo
Total, Other (not including serious) Adverse Events
# participants affected / at risk	34/185 (18.38%)	34/188 (18.09%)	41/184 (22.28%)	32/179 (17.88%)	36/181 (19.89%)
Infections and infestations
Nasopharyngitis ^†
# participants affected / at risk	19/185 (10.27%)	15/188 (7.98%)	23/184 (12.50%)	14/179 (7.82%)	16/181 (8.84%)
Nervous system disorders
Headache ^†
# participants affected / at risk	8/185 (4.32%)	8/188 (4.26%)	11/184 (5.98%)	5/179 (2.79%)	16/181 (8.84%)
Psychiatric disorders
Libido decreased ^†
# participants affected / at risk	10/185 (5.41%)	9/188 (4.79%)	6/184 (3.26%)	9/179 (5.03%)	2/181 (1.10%)
Reproductive system and breast disorders
Erectile dysfunction ^†
# participants affected / at risk	8/185 (4.32%)	7/188 (3.72%)	10/184 (5.43%)	10/179 (5.59%)	7/181 (3.87%)

Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data

Dr. Rassman’s Comment: I want to call you attention to the chart here which discusses sexual side effects between these medications and the placebo. To find out the incidence of the Libido problems and Erectile Dysfunction from this study you must subtract the placebo numbers. If this is true, the incidence is relatively low.

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