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Another article on micxroneedl;ing and minoxidil used in combination as a good treatment for early hair loss

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 2017 Oct 13. doi: 10.1080/14764172.2017.1376094. [Epub ahead of print]

Randomized trial of electrodynamic microneedle combined with 5% minoxidil topical solution for the treatment of Chinese male Androgenetic alopecia.

Bao L1Gong L1Guo M1Liu T1Shi A1Zong H2Xu X1Chen H1Gao X1Li Y1.

Abstract

BACKGROUND:

In treating androgenetic alopecia, 5% minoxidil is a commonly used topical drug. By using electrodynamic microneedle at the same time may increase absorption of minoxidil and further stimulate hair growth.

OBJECTIVE:

A 24-week, randomized, evaluator blinded, comparative study was performed to evaluate the efficacy of treating Chinese male androgenetic alopecia using microneedle combined with 5% minoxidil topical solution.

METHODS:

Randomized subjects received topical 5% minoxidil (group 1, n = 20), local electrodynamic microneedle treatments (group 2, n = 20), or local electrodynamic microneedle treatments plus topical 5% minoxidil (group 3, n = 20). A total of 12 microneedle treatments were performed every 2 weeks with 2ml 5% minoxidil delivery in group 3 during each microneedle treatment. Patient receiving topical 5% minoxidil applied 1 ml of the solution twice daily over the course of the study. A total of 60 Chinese male subjects with Norwood-Hamilton type III-VI androgenetic alopecia were treated.

RESULTS:

The mean improvement in total hair density from baseline to 24 weeks was 18.8/cm2 in group 1, 23.4/cm2 in group 2, and 38.3/cm2 in group 3. The hair growth in the 3 groups was significantly different (P = 0.002), but there were no significant differences in toxicity found between the 3 groups.

CONCLUSIONS:

Treatment with microneedle plus topical 5% minoxidil was associated with the best hair growth.

KEYWORDS:

Androgenetic alopecia; Chinese; microneedle; minoxidil



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