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PFS and its cause

Jonny Smith Reply 02:16 A+ A-

Based on all the available evidence (with 1-4% of people getting PFS who take finasteride), the most likely etiology of PFS is that the gene for 5a-reductase type 2, SRD5A2, is epigenetically silenced in key tissues responsible for sexual function, including in the brain, through DNA methylation. Gene methylation is a well-described process that is known to occur with many genes and with this...

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